This application note demonstrates the performance of the Watchmaker DNA Library Prep Kit with TAPS+ on the Element AVITI™ platform for methylation-based liquid biopsy research using plasma cfDNA.
Highlights
- Demonstrates >95% mapping efficiency and high-quality genome-wide methylation profiling from plasma cfDNA.
- Shows strong concordance with ONT native methylation sequencing for AI-based tumor scoring.
- Highlights a scalable workflow for methylation-based liquid biopsy research with the potential to simultaneously profile methylation and genomic variants from a single library.
