Visit Watchmaker at AACR 2026

San Diego, CA | April 17 - 22, 2026 | Booth 1815

AACR brings together the global oncology research community to explore the next wave of tumor biology, biomarker discovery, and translational research.

At Watchmaker Genomics, we're focused on enabling deeper biological insight through next-generation NGS innovation - delivering high-quality genetic and epigenetic data from the same sample, even when material is limited or degraded.

TAPS+ enables nondestructive methylation sequencing for integrated oncology insights

TAPS+ is a bisulfite-free sequencing method designed for direct detection of 5-methylcytosine (5mC); preserving DNA integrity and base complexity.

Unlike traditional bisulfite approaches, TAPS+ avoids DNA degradation and collapse of sequences from four to three bases, and enables:

• Simultaneous genomic variant and methylation analysis from a single library
• Improved library complexity and more uniform coverage
• Compatibility with clinically relevant oncology samples, such as FFPE and cfDNA

By preserving the original DNA sequence, TAPS+ supports high-quality epigenetic profiling alongside genetic analysis - particularly valuable when working with limited or degraded tumor samples. 

EquiPlex: A novel CRISPR-based, nondestructive library normalization technology designed to transform how labs normalize and pool samples

• Eliminates calculations and serial dilutions
• Reduces sample dropout and uneven pooling
• Enables efficient, scalable automation

Want to stay in the know? Sign up for updates on progress here.

Watchmaker Genomics Poster

Non-destructive methylation sequencing enables concurrent detection of genetic and epigenetic variation in FFPE and cfDNA samples

Poster: #1951
Date: Monday, April
Time: 9:00am - 12:00pm

Labcorp x Watchmaker Poster

Utility of TAPS+: a positive-readout methylation sequencing approach for high-fidelity epigenetic profiling

Poster: #3213
Date: Monday, April 20
Time: 2:00pm - 5:00pm

• DNA Library Prep Kits – Optimized for oncology-relevant sample types, including FFPE, delivering better rare variant detection with high efficiency and reproducibility
• RNA Library Prep Kits – Using a specifically-engineered reserve transcriptase for highly sensitive fusion calling, even with cfDNA and FFPE
• Equinox Library Amplification Kits - Scalable, high-performance library amplification solutions designed for minimal bias and maximum sensitivity 

Missed a poster or can't make it to AACR?

Have questions about implementing TAPS+, integrating genetic and epigenetic analysis, or improving library performance from challenging tumor samples?

Visit the AACR 2026 Meeting Page for more information about the conference.