Utility of TAPS+: A positive-readout methylation sequencing approach for high-fidelity epigenetic profiling (Labcorp)

This poster presents data from a collaboration between Watchmaker and Labcorp, evaluating methylation sequencing approaches using TAPS+ and a negative-readout methylation workflow.

• Higher library yields and improved methylation accuracy
• Reduced background noise and stronger detection of biologically relevant methylation signals
• Preserved sequence complexity, enabling robust performance from cfDNA and tissue samples
• Consistent methylation profiling across both Illumina and Ultima sequencing platforms

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